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KMID : 0369819940240020105
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 2 p.105 ~ p.108
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Evaluation of Ulcerogenic Activity of Ketoprofen Gel
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단현광/Tan HK
지상철/전흥원/Chi SC/Jun HW
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Abstract
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The ulcerogenic activity of a 3% ketoprofen gel (ID-GEL) after its transdermal application in rats was determined with the Litchfield and Wilcoxon method in reference to the oral administration of ketoprofen in a suspension. The UD50 (dose producing ulcers in 50%, of the rats tested) of ID-GEL after its transdermal application was approximately 4 times greater than that after the oral administration of the drug, indicating that the ulcerogenic activity of ketoprofen was much lowered with its transdermal application.
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KEYWORD
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Ketoprofen, Gel, Ulcerogenic activity, Rat
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